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Bioengineering

The Bioengineering Laboratories occupy approximately 2000 square feet of laboratory space i nteh Sciences Building.  Resources include:

  • 3D printer (Robocast Assisted Deposition System EBD-2011-05) system is equipped with a multi-dimension stage controller for the generation of scaffolds for tissue engineering. The system consists of an extrusion based delivery system that has a syringe pump controlling on the inlet and robotic assisted extrusion of scaffold parts on the outlet.
  • ATR-FTIR.  The Nicolet iS10 ATR-FTIR system offers an unprecedented level of integration  between the spectrometer, software and the accessory with standard features like SPV, QCheck and Advanced ATR correction.
  • Nanodrop 2000.  The NanoDrop 2000 is a microvolume spectrophotometer for measuring DNA, RNA, and protein.  Using g the patented sample retention system* the NanoDrop 2000 accurately measures samples as small as 0.5 μL, and reports samples concentration, purity ratios, and full spectral data.
  • Fluorometer.  The QuantiFluorTM-P fluorometer is a lightweight, handheld instrument configured for many of the fluorescent probes commonly used in nucleic acid and protein quantitation.

Biomechanics/Materials Testing

The Biomechanics/Materials Testing Laboratory occupies approximately 3900 square feet of laboratory space in the Sciences Building. Available resources include:

  • Casting, Mechanical Testing, and X-ray Diffraction Porcelain Processing
  • Corrosion Testing and Atomic Absorption
  • Thermal Analysis
  • Atomic Absorption Spectrometry
  • Minolta CR-210 Chromameter
  • EG&G 273A Potentiostat/Galvanostat (Princeton Applied Research) and a corrosion cell
  • Solartron 1289Z Electrochemical Measurement System
  • Ticast Super R (Selec Inc., Japan) for casting titanium alloys; Lindberg tube furnace and a Ney Centurion Q200 vacuum furnace
  • Nd:YAG laser welding machine (Neo-Laser L, Girrbach, Dental-Systeme, Germany)
  • Instron Models1125 (20,000 lbs. maximum) and 1011 (1000 lbs. maximum) universal test machines; Struers FM-7 digital microhardness tester (load range 50-1000 g).
  • Mitutoyo Surftest-401 profilometer to measure surface topography
  • 2 Buehler Isomet low-speed saws; Vector-Beta, Simplimet3, Ecomet3, and Vibromet2 polishing stations; and gold, carbon, and nickel coating systems
  • Shimadzu TGA-50 Thermogravimetric Analyzer; Shimadzu DSC-50 Differential Scanning Calorimeter; SHhimadzu TMA-50H Thermomechanical Analyzer; TMA-50H, a thermomechanical analyzer
  • The Rigaku Miniflex CN2005 x-ray diffractometer

Histology

The Histology Core Facility provides oversight and technical support for

  1. a histology laboratory,
  2. a scanning electron microscope,
  3. confocal and microscopy image analysis, and
  4. micro-computed tomography and image analysis.

Each component of the core facility is equipped as follows:

The Histology Core Laboratory is a 4000 square foot facility equipped with regular laboratory hardware, including:

  • Leitz 1512 microtome
  • VIP Tissue Tek processing station
  • PELCO Biowave Microwave
  • Paraffin embedding station
  • Buehler Isomet low speed saws (2)
  • Buehler grinding/polishing devices
  • Slide warmer
  • Histo-orientator
  • Water bath (2)
  • Light microscopes
  • Knife sharpener
  • Dual headed microscope (2)
  • Slide dryer
  • Paraffin oven

The Scanning Electron Microscope, a JEOL JSM-6010LA, uses a field emission gun with cold cathode. The resolution is 1.5 nm in secondary electron imaging (SEI) and 3.0 nm in backscattered electron imaging (BEI) at 30 kV. The airlock specimen chamber allows up to a 32 mm diameter sample, and the size can also be up to 150 mm without the airlock

  • motorized X-Y stage
  • automatic SEM condition setup based on sample type
  • simultaneous multiple live image and movie capture
  • easy sample navigation at 5x-300,000x magnifications
  • quantitative and qualitative elemental analysis
  • low and high vacuum operation
  • wireless capability

The Microscopy-Image Analysis Facility contains:

  • Leica SP5 (2010 model) confocal system with four lasers and five detectors used with an upright microscope: Laser lines 405, 458, 488, 514, 543, 561, 633.
  • Nikon eipfluorescent microscope equipped for digital monochrome and color image analysis, an X-Y-Z encoded motorized stage, Pentium computer and Elements software, as well as a secon d Nikon microscope with a Sony DXC-390 camera and Bioquant NOVA software for bone histomorphometry.
  • Zeiss Axioplan microscope with a SPOT color camera for digital capture.
  • Leica DMRXE microscope with color camera for digital capture.

The Micro-Computed Tomography Facility consists of aScanCo MicroCT 35 Scanner with two terminals.

  • Windows-based microcomputer for image analysis.
  • Associated Windows-based software included Mimics, Geomagic Studio, Strand 7 Finite Element software, Analyse, and Imaris.
  • Windows-based microcomputer set up to use with Bioquant Osteo.

Resources Available in Other Departments

In addition to these facilities, the Department of Biomedical Sciences (BMS) houses the following core equipment, located on the fourth floor of the main BCD building and the second floor of the Sciences Building:

  • Agilent 2100 Bioanalyzer
  • Two BioRad CFX96 real-time PCR instruments
  • MJR gradient thermocycler
  • Kodak Image Station
  • Nucleovisino image station
  • Beckman L-60 ultracentrifuge
  • Two Beckman J2-21 centrifuges
  • Beckman GS-6R tabletop centrifuge
  • Eppendorph refrigerated microcentrifuge
  • Savant Speed-Vac 5200 and lyophilizer
  • Labline shaking incubator
  • Packard Cobra auto-gamma counter
  • Packard 1900 TR liquid scintillation counter
  • Perkin Elmer 1450 Luminescence center
  • Beckman DU-53- Spectrophotometer
  • Molecular Devices 96 well plate reader
  • Cell culture facilities with a tissue dissection hood, laminar flow biosafety hood, and associated CO2 incubators and microscopes
  • 4C coldroom
  • Microm HM 500 M cryostat
  • Complete darkroom with sinks and automated film developer
  • -80C freezers
  • Glassware dishwasher
  • UV Crosslinker
  • Tissue homogenizers and sonicator

The Advanced Technology Clinic is housed in separate rooms in the third-floor clinic. It contains ITERO and D4D 3D imaging equipment for milling inlay and onlay prosthetics from intraoral images.

The Biopsy Service is an oral histopathology service for clinicians, and currently approximately 8500 cases are processed annually. All specimens have been archived in paraffin blocks, a rich resource of tissue representing a variety of head and neck diseases, included neoplasms. These cases can be retrieved by a variety of parameters, including diagnosis, allowing retrospective analysis of a variety of diseases by immunohistochemistry, PCR, in-situ hybridization, gene rearrangement studies, etc.

The Center for Excellence is a newly established Center of Excellence and builds on the dental school's longstanding pipeline programs that address issues like access to care and minority enrollment. The program is funded by a five-year, $3.4 million grant from a U.S. Department of Health and Human Services' Center of Excellence program, and supports students wanting to earn a master's degree in education for health care professionals.

The Center for Maxillofacial Prosthodontics Clinic is the only such center in North Texas, providing interdisciplinary treatment for patients with both oral and facial disfigurements. A certified clinical Anaplastologist concentrates on advanced prosthetics solutions and digital technologies in the treatment of patients with acquired or inherited facial defects. This clinic specializes in restoring  normal appearance and function to patients with acquired or congenital defects of the dental, oral and facial  structures, as a result of disease, trauma, cancer treatment, or birth defects. This can be accomplished by placement of implant-supported devices (artificial noses, ears, eyes, teeth) or other like procedures. The clinic provides access to a unique population of patients for clinical research and an important retrospective patient database.

The Functional Analysis Facility is a multi-disciplinary center of excellence whose mission is to address the causes, consequences, and treatment of craniofacial deformities through basic and clinical research. the facility maintains a fully equipped clinical facility dedicated to clinical research.  This facility consists of a small waiting room, a reception area, a sterilization area, and three fully-functional dental operatories.  The clinic is made available to other investigators conducting clinical craniofacial research.  Next to the clinic are two laboratories to support and extend the research conducted in the clinical facility.  These laboratories include a 300 square foot computer/imaging laboratory and a 500 square foot laboratory dedicated to  the collection of data relating to functional parameters of human oral and craniofacial activity. Functional lab equipment includes:

  • OptotrakOp® 3020 Position Sensor (Northern Digital) for measuring movements
  • Bite force transducer with amplifier and oscilloscope
  • Equipment for measuring electromyography - amplifiers, leads, etc.
  • Equipment for measuring masticatory performance - templates for Cuttersil tablets, sieves, balance, oven, etc.

In addition to this equipment, the lab contains equipment for scanning 3D objects:

  • 3D (Motionview®) laser scanner and software for scanning models

The Health Services Research Center consists of a number of offsite clinics, including the dental clinic at the Dallas County Juvenile Detention Center, the Dallas County Jail and several Community Dental Care locations.  The center also has ties to the Dallas Independent School District through the school-based dental sealant program, in which approximately 5,000 elementary school students are screened and/or treated each year.  With the exception of the Dallas County Jail clinic, these programs serve primarily pediatric populations and all are excellent settings for clinical and/or health services research.  Approximately 15,000 patients per year are treated. Epidemiologic studies of oral health disparities and health care delivery are currently underway at several of these facilities. The department also provides health promotion/disease prevention programs for Dallas County and beyond, and is currently beginning a pilot study on alternate approaches to prevention of early childhood caries.

The Oral and Maxillofacial Imaging Center offers sophisticated diagnostic services to diagnose and manage, conduct clinical research concerning disorders of the head and neck region, including temporomandibular joint dysfunction, dental implant site assessment, orthodontics, craniofacial anomalies, salivary gland dysfunction, trauma, and general pathology. Imaging technology includes digital projection radiography including panoramic radiography, contrast radiography, cone-beam computed tomography, and digital photography, as well as facilities for computerized study and secondary rendering for digital images.

The Pediatric Craniofacial Clinics: Pediatric Dentistry manages a 6 chair graduate clinic at Children's Medical Center and a 5 chair graduate clinic at Texas Scottish Rite Hospital for Children that provide oral care to a large number of children suffering from genetic and acquired disorders, which include craniofacial and dental malformations.  The Department of Pediatric Dentistry also maintains and staffs five community-based clinics for high risk children from low income or underserved families at the Bluitt Flowers, DeHano-Saldibar, Southeast, Vickery Meadow and East Dallas Community Dental Care Clinic.  In additional to these clinics, the Department of Pediatric Dentistry staffs the multidisciplinary craniofacial team at Children's Medical Center of Dallas.

The Pre-Doctoral Implant Clinic is the diagnostic and treatment center for the Pre-Doctoral program in Implant Dentistry.  the clinic consists of a diagnostic and treatment planning section and five clinic chairs for surgical consultations, impression procedures, and final restorative procedures and, as needed, will use additional clinical chairs in the 3rd and 4th year restorative clinics.  Radiographic and surgical guides are made in  the adjacent implant laboratory which has a drill press, positive pressure Bioster forming unit and other supportive instrumentation to manufacture the guides.  The implants and restorative components ar provided from an Educational Grant from Straumann.

The Stomatology Center specializes in a team approach for diagnosis and management of rare and severe diseases and disorders of the oral mucosal tissues that are difficult to diagnoses and manage.  The include but are not limited to mucocutaneous disorders, oral hypersensitivity reactions, candidosis, AIDS-related diseases and disorders, burning mouth and tongue syndrome and problems resulting from chemotherapy, radiation therapy or abuse of illicit drugs or alcohol.  Internationally recognized as a unique referral site for patients seeking medical help for rare conditions, doctors are able to utilize sophisticated diagnostics not normally available in dental offices.  The Salivary Dysfunction Clinical and Stomatology Research Laboratory enhances collaboration among medical and dental specialists in the care fo Sjögren's patients and offers a unified and organized way of referring patiens with Sjögren's  Syndrome to specialits in ophthalmology, rheumatology, gastroenterology, pulmonary medicine, dermatology and psychology as well as oral/salivary dysfunction.

Other Clinical Facilities Available to BCD Researchers

Texas A&M Baylor College of Dentistry Clinics:  TAMBCD has a history of over 100 years as a fully-accredited dental school with developed programs in all areas of dental education.  Approximately 105,000 patient visits per year occur in TAMBCD clinics and nearly 300,000 individuals are seen during community service activities.  TAMBCD has complete state-of-the-art clinical operatories, laboratories, diagnostic facilities, and computerized dental simulation laboratories that are available for approved clinical research by faculty and mentored student trainees.  TAMBCD clinics, which contain 306 chairs, provide the College's primary source for instruction in clinical dentistry.  In addition to large clinics devoted to general restorative dentistry and undergraduate dental student instruction, there are graduate clinics in Advanced Education in General Dentistry, Endodontics, Orthodontics, Pediatric Dentistry, Periodontics, Prosthodontics, and Oral and Maxillofacial Surgery, as well as graduate programs in Dental Public Health and Oral and Maxillofacial Pathology.

Technology Development Office

The Technology Development Office (TDO) is housed in the Office of the Associate Dean for Research and Graduate Studies. The functions of the TDO are to

  • facilitate translation al research and technology development, from the identification of promising technologies, funding initial research, protecting intellectual property, and aiding in technology transfer and commercialization,
  • liaise with BCD alumni and with the dental community at large, encouraging and fostering creativity and ideas regarding novel treatment modalities,
  • create and expand the research and development scope of BCD,
  • interact and cooperate with outside agencies and companies to develop sponsored research opportunities  for translational research, clinical trials and product testing,
  • create opportunities for technology transfer from BCD.
Last edited by: tarpley 09/01/2014

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