|
Although, it is true that we do not know the cause of lichen planus, most practitioners and patients with lichen planus will tell you
that they can document the development of lesions when their stress levels increase. The information below is published to provide some facts that we know occur in the body. Mason differentiated between the arousal of the sympathetic adrenal-medullary system by the fight-flight response (based on work by Selye) and the pituitary adrenocortical response. It
has been documented that if the sympathetic adrenal-medullary system is activated excessively, persistently and too often, illness and disease may occur. The release of catecholamines, epinephrine and norepinephrine by the adrenal
medulla and/or sympathetic nerve endings is believed to induce many of the pathological states associated with psychological stress: increased blood pressure, cardiac arrhythmias and sudden death.Stress and stress-related illnesses have been studied extensively in the last 20 years. The results clearly indicate that stress, especially chronic stress, has profound effects on the body. The well-known
Framingham, Mass. Heart study identified the type A personality and associated it with a doubling of the risk of coronary heart disease in men and women. Animals subjected to repeated stress showed significant decreases in the
total number of mononuclear cells, especially T cells, in the spleen and blood. Chronic stress can cause a reduction in mitogenesis, alterations in lymphocytes, reductions in the ratio of T-helper cells to T-suppressor cells and an
elevation in the number of natural killer cells. Life events that produce chronic stress have been shown to have a wide range of effects on the body. Recently a major emphasis has been placed on
the patient's ability to cope with the chronic stress of daily life. Adverse life events have also been documented as occurring before the onset of functional abdominal pain, alopecia areata, headaches, cancer, heart disease, low
back pain, and psoriasis. The above is in part from: Assessing the Characteristics of Patients with Oral Lichen Planus: Burkhart, et al. JADA 127:5, 1996.
|