Darren M. Roesch
Department of Biomedical Sciences
3302 Gaston Ave
Dallas, Texas 75246
Education and Post-Graduate Training
B.S., Microbiology and Cell Science, University of Florida
Ph.D., Pharmaceutical Sciences - Pharmacodynamics, University of Florida
Postdoctoral Fellow, Division of Endocrinology, Georgetown University
Chercheur Étranger, Collège de France, Paris, France
7290 Dental Pharmacology, 8380 Medical Pharmacology, 9110 Applied Pharmacology; 5212 Clinical Pharmacology, 6870 Physiology, 6770 Neuroscience, 7410 Integrative Sciences, 3340 Biomedical Sciences
Dr. Roesch’s expertise spans the realms of physiology, neuroscience, and pharmacology. He participates in team-teaching physiology and neuroscience to dental and dental hygiene students and is the coordinator of all pharmacology courses in the dental curriculum.
He has recently returned to graduate school and is working to complete an M.S. in Education for Healthcare Professionals from Texas A&M Health Science Center. His scholarly activities focus on the teaching and learning of biomedical sciences in dentistry. In addition to writing scholarly reviews of biomedical topics relevant to dentistry, Dr. Roesch conducts and writes about classroom experiments designed to improve the teaching and learning of biomedical sciences. He is particularly interested in leveraging technology to enhance learning experiences and in designing active-learning experiences that move beyond the traditional didactic lecture.
C-peptide as a Biomarker and Mediator of Central Sensitization in TMD
Patients with temporomandibular joint disorders (TMDs) frequently progress to chronic generalized pain. This condition of multiple pain symptoms is known as "Central Sensitization".
Stemming from his long-standing interest in neuroendocrinology, Dr. Roesch is currently conducting pilot studies to determine if the peptide hormone, C-peptide, could be either a biomarker or mediator of Central Sensitization in patients with chronic TMD. C-peptide is a molecule that, like the hormone insulin, is cleaved from the long peptide precursor, proinsulin, in the beta cells of the Islets of Langerhans. Proinsulin has long been considered to be nonfunctional because, unlike insulin, no links to metabolism were initially found upon its discovery. However, recent studies conducted in type 1 diabetics who do not make C-peptide suggest that this hormone plays a role in modulating both pain and heart-rate variability. In addition, the recently completed, large-scale, OPPERA study of patients with chronic TMD found several genetic predispositions and autonomic changes in TMD patients; these findings mildly implicated C-peptide as a mediator or biomarker of Central Sensitization in patients with chronic TMD. Therefore, Dr. Roesch is currently conducting pilot studies to determine if further study of the role of C-peptide in Central Sensitization in patients with chronic TMD is warranted.
NIH/NICHD, HD047890 (PI); 07/04-06/08. Effects of in utero exposure to anti-epileptic drugs on fetal neuronal structural and functional damage
NIH/NIA, R03, AG022624 (PI); 05/04-04/06. Ovarian senescence and adrenal hormone responses
Georgetown Intramural Research Grant (PI); 07/04-06/05. Estrogen, estrogen receptors, and body weight homeostasis
The Center for Biological Modulators, Korea Research Institute of Chemical Technology (PI); 01/03-09/05. Development of selective estrogen receptor modulators for the prevention of postmenopausal obesity and cardiovascular disease
National Kidney Foundation of the National Capital Area, Inc. (PI); 08/03-07/04. Ovarian steroid modulation of aldosterone secretion
NIH/NHLBI, F32, National Research Service Award (PI); 08/00-07/03. Effect of estradiol on aldosterone responses and actions
Roesch DM, Keller-Wood M. Progesterone rapidly reduces arterial pressure in ewes. Am J Physiol. 1997 Jan; 272 (1 Pt2): H386-91.
Roesch DM, Keller-Wood M. Differential effects of pregnancy on mineralocorticoid and glucocorticoid receptor availability and immunoreactivity in cortisol feedback sites. Neuroendocrinology. 1999 Jul;70(1):55-62.
Roesch DM, Tian Y, Zeng W, Shi M, Verbalis JG, Sandberg K. Estradiol attenuates angiotensin-induced aldosterone secretion in ovariectomized rats. Endocrinology. 2000 Dec;141(12):4629-36.
Roesch DM, Blackburn-Munro RE, Verbalis JG. Mineralocorticoid treatment attenuates activation of oxytocinergic and vasopressinergic neurons by icv ANG II. Am J Physiol Regul Integr Comp Physiol. 2001;280(6):R1853-64.
Roesch DM, Tian Y, Verbalis JG, Sandberg K. Rat model for investigating ACTH-independent angiotensin-induced aldosterone secretion. J Renin Angiotensin Aldosterone Syst. 2000 Mar;1(1)36-9.
Wu Z, Maric C, Roesch DM, Zheng W, Verbalis JG, Sandberg K. Estrogen regulates adrenal angiotensin AT1 receptors by modulating AT1 receptor translation. Endocrinology. 2003 Jul:144(7):3251-61.
De Mota N, Reaux-Le Goazigo A, El Messari S, Chartrel N, Roesch D, Dujardin C, Kordon C, Vaudry H, Moos F, Llorens-Cortes. Proc Natl Acad Sci USA. 2004 Jul 13;101(28):10464-9.
El Messari S, Iturrioz X, Fassot C, De Mota N, Roesch D, Llorens-Cortes C. Functional dissociation of apelin receptor signaling and endocytosis: Implications for the effects of apelin on arterial blood pressure. J Neurchem. 2004 Sep; 90 (6): 1290-301.
Roesch DM. Effects of selective estrogen receptor agonists on food intake and body weight gain in rats. Physiol Behav. 2006 Jan 30;87(1):39-44.
Zheng W, Shi M, You SE, Ji H, Roesch DM. Estrogens contribute to a sex difference in plasma potassium concentration: A mechanism for regulation of adrenal angiotensin receptors. Gend Med. 2006 Mar;3(1):43-53.
Dutton MA, Green BL, Kaltman SI, Roesch DM, Seffiro TA, Krause ED. Intimate partner violence, PTSD, and adverse health outcomes. J Interpers Violence. 2006 Jul;21(7):955-68.
Ji H, Zheng W, Falconetti C, Roesch DM, Mulroney SE, Sandberg K. 17beta-estradiol deficiency reduces potassium excretion in an angiotensin type 1 receptor-dependent manner. Am J Physiol Heart Circ Physiol. 2007 Jul;293(1):H17-22.
Kolluru S, Roesch DM, Akhtar de la Fuente A. A multi-instructor, team-based, active-learning exercise to integrate basic and clinical sciences content. Am J Pharm Educ. 2012 Mar 12;76(2):33.
Roesch, DM. (2012). The pharmacology of ozone in dental biofilms: antimicrobial, antiadhesive, and remineralization effects. In: R Sethi, S Manchanda, and V Sethi (Eds.), Ozone and Ozone Depletion: Sources, Environmental Impact and Health (pp. 25-30). Nova Science Publishers.
ADEA Summer Program for Emerging Academic Leaders
Intramural Research Award, Georgetown University Medical Center
Joseph M. Krainin, M.D., Memorial Young Investigator Award, National Kidney Foundation of the National Capital Area
Ruth L. Kirchstein National Research Service Award, National Institutes of Health
Levitt Oral Competition Award, University of Florida
Novel Drug Target Discovery Award, Korea Research Institute of Chemical Technology
Poste vert award, Institut National de la Santé et de la Recherche Médicale (INSERM), France