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Kornman et al described a genetic marker that identifies adults who, with a bacterial challenge, are highly susceptible for severe periodontitis. The association of severe periodontitis with smoking and the IL-1 genotype reported in their paper suggests a role for these factors in the pathogenesis of periodontitis.
Kornman et al. The interleukin-1 genotype as a severity factor in adult periodontal disease. J Clin Periodontol 1997; 24: 72-77.
A genetic susceptability test for periodontal disease is currently being marketed by Medical Science Systems of Flagstaff, AZ. Telephone 888/677-1778.
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