ADVANCED BIOLOGY OF MINERALIZED TISSUES (5244). Overview of the advanced biology of mineralized tissues and their roles in oral health and disease. The course will cover the basic molecular biology of teeth and the skeleton, including bone and cartilage. The course will explore other aspects of systemic biology, such as local and systemic factors that control calcium and phosphate balance, as well as recent advances in molecular biology and research methodologies (molecular biology, gene targeting and histology at both light and electron microscopic levels ) for mineralized tissue research. Feng - 2 sem. hrs.
APPLIED BIOSTATISTICS (5222). Overview of applied biostatistics with an emphasis on oral health research. Training includes computer-based instruction in data analysis using SPSS. Schneiderman - 2 sem. hrs.
ADVANCED BIOSTATISTICS (5324) Prerequisites: CS5222 and 5122 or equivalent. Advanced biostatistical methods, including multivariate and longitudinal analysis; computer simulations; applications in craniofacial biology. Buschang - 2 sem. hrs
ADVANCED HUMAN CRANIOFACIAL DEVELOPMENT AND CRANIOFACIAL ANOMALIES (5V73). Detailed investigation of the basic processes and mechanisms of postnatal growth and adaptation of the craniofacial region. This course emphasizes the areas of controversy surrounding the current understanding of the factors influencing postnatal craniofacial growth and form, the adaptive capabilities of growth and form, the adaptive capabilities of craniofacial tissues, the effect of altered function on craniofacial growth and form, and the influence of treatment on craniofacial growth and form. Also considered are theories of craniofacial growth. Svoboda - 1 sem. hr. Variable
ADVANCED NEUROSCIENCE (5360). Prerequisite: 5301 or equivalent. Advanced concepts of neuroscience are presented with an in-depth coverage of membrane and system function. Hutchins/Wong - 1 sem. hr.
APPLIED MEDICAL PHYSIOLOGY (5312). Prerequisite: 5611 or equivalent. Basic physiology of the cardiovascular, respiratory and renal systems. Each area is expanded to include physiology problems seen clinically as they relate to the dental intern. Bellinger - 2 sem. hrs.
BIOLOGY OF BONE AND MINERALIZED TISSUES (5377). Overview of modern studies of bone structure, function and adaptation with specific relevance for the craniofacial region. Faculty - 1 sem. hr.
CARTILAGE BIOLOGY (5278). This course familiarizes the student with the biology of cartilaginous tissues, with emphasis on the structure and metabolism of the chondrocyte and its matrix. Implications for the biomedical properties of the tissue and for the development of degenerative changes are explored. Hinton/Svoboda - 1 sem. hr.
CELLULAR AND MOLECULAR BIOLOGY (5307). Intermediary metabolism of protein, protein synthesis, nucleic acid metabolism and biochemical endocrinology. Faculty -2 sem. hrs.).
CELLULAR AND MOLECULAR BIOLOGY OF ORAL AND CRANIOFACIAL TISSUES I (5V40). Prerequisites: 5208 or equivalent; 5306 or equivalent. A general survey intended to provide background information concerning the methods and theory of modern cellular/molecular biology. This course lays the groundwork for more advanced study, aids those interested in incorporating cellular/molecular approaches into their research work and enables one to read, understand and evaluate current scientific literature. Qin - 2 sem. hrs. Variable
CELLULAR AND MOLECULAR BIOLOGY OF ORAL AND CRANIOFACIAL TISSUES II (5V42). Processes of epithelial-mesenchymal interaction as related to odontogenesis, amelogenesis, dentinogenesis, collagen formation, intracellular and extracellular calcium homeostasis, plaque and calculus and wound healing. Svoboda - 1 sem. hr. Variable
CLINICAL PHARMACOLOGY (5214). Selection and evaluation of dentally related drugs and review of current literature; seminar format. Limited to clinical specialty students. Sharma - 1.5 sem. hrs.
DIRECTED READINGS (5V93, 5V94, 5V95). Individualized courses for single students involved in in-depth study of specific topics in the biomedical sciences. Faculty. Variable
DISSERTATION (5V99). Course used by students after achieving candidacy for research and preparation of Ph.D. dissertation. Faculty. Variable.
EVOLUTIONARY AND FUNCTIONAL MORPHOLOGY (5376). Comparative anatomy and evolution of craniofacial structure, with emphasis on current techniques of electrophysiology, kinesiology and musculoskeletal biomechanics of orofacial function. Dechow - 1 sem. hr.
GENERAL HISTOLOGY (5402). General histology and microscopic anatomy of the four basic tissues. Laboratory study of electron micrographs and computerized images is employed. Opperman - 3 sem. hrs.
GENETIC EPIDEMIOLOGY (5243). Introduction to genetic epidemiology and associated study design and data analysis for identifying disease-gene associations. Mitchell and faculty – 2 sem. hrs.
GROSS ANATOMY (5603). Conceptual and functional basis for understanding the macroscopic structure of the human body utilizing laboratory dissection of human cadavers. Regional anatomy of the back, thorax, upper limb and head is emphasized. Hutchins - 4 sem. hrs.
GROWTH AND MECHANISMS OF DEVELOPMENT (5V69). Normal prenatal growth and development. Patterns and mechanisms of growth and maturation. Svoboda - 1 sem. hr.
HEAD AND NECK ANATOMY (5V04). Special emphasis on surgical anatomy and distribution of nerves and vasculature of particular interest in the field of dentistry. Hutchins - 1.5 sem. hrs.
IMMUNOLOGY (5251). Update on the principles of immunology with an emphasis on oral aspects and related diseases. Newman - 2 sem. hrs.
MAMMALIAN PHYSIOLOGY (5611). Basic physiological principles of cells, muscle, nerve, blood, heart, circulation, respiration, digestion, excretion, and central nervous system in maintaining homeostasis. Classical laboratory experiments are used to demonstrate these principles. Wong -4 sem. hrs.
MICROBIOLOGY (5208). Introduction to basic microbiology with emphasis on oral and medical microbes, taxonomy and microbial physiology. Taught in conjunction with dental curriculum. Additional readings and discussion for graduate students. Honeyman - 3 sem. hrs.
MICROBIOLOGY LABORATORY (5210). Introduction to classical laboratory methods of microbial staining, microscopy, isolation and cultivation. Taught in conjunction with 5208. Honeyman - 1 sem. hr.
MICROSCOPY, IMAGING, AND ASSOCIATED TECHNIQUES (5127). Principles and methods of microscopy including the usage of scanning electron, light, fluorescent, and confocal microscopes, and computer imaging techniques. Spears - 2 sem. hrs.
NEUROSCIENCE (5301). Lectures and laboratory sessions on gross and microscopic anatomy of the human central and peripheral nervous system. Neurophysiology of the central nervous system, peripheral nerves, special sense, autonomics and clinical mediation. Hutchins - 2 sem. hrs.
ORAL HISTOLOGY (5205). Origin and development of the dental tissues and their related structures. Current publications and research reports are used to provide students with an opportunity to investigate some phase of active interest to them and their anticipated future interest in practice. Spears - 3 sem. hrs.
ORAL MICROBIOLOGY (5350). Prerequisites: 5208, 5210 or equivalent. The environment of the mouth is described and its relation to the endogenous and exogenous oral microbiota; relationship between disease and bacterial species; discussion of species differences; molecular mechanisms of bacterial pathogenesis; and host response to oral microbes. Ezzo -3 sem. hrs.
PHYSICAL GROWTH AND MATURATION (5V75). Patterns and mechanisms of postnatal growth and maturation. Buschang - 0.5 sem. hr. Variable
RESEARCH AND SPECIAL PROBLEMS (5V96, 5V97). Concentrated investigation in any area of biomedical sciences. This course is appropriate for individualized laboratory rotations or research. Faculty. Variable
RESEARCH DESIGN AND METHODOLOGY (5221). An introduction to the research process; sufficient background in research design and methodology is provided to enable students to critically evaluate literature and assist in the formulation of research projects. Also includes discussion of rules and regulations for human and animal research. Buschang - 2 sem. hrs.
RESPONSIBLE CONDUCT IN BIOMEDICAL RESEARCH (5126). A discussion of issues relating to ethical conduct and research. Offered spring semester of odd years. Dechow - 0.5 sem. hr.
SEMINAR: CURRENT ISSUES IN BONE AND MINERALIZED TISSUE BIOLOGY (5V81). Topics of current importance in bone and mineralized tissue biology. Dechow - 1 sem. hr.
SEMINAR: CURRENT ISSUES IN SCIENCE (5190). Guest lectures, workshop lectures and discussion; includes topics of current interest to program faculty and students and of general interest in the biomedical sciences. Faculty - 1 sem. hr.
SENSORY NEUROBIOLOGY AND PAIN (5263). An overview of the various sensory systems is explored with the primary emphasis on the processing of pain and temperature information from the craniofacial complex. Hutchins - 1 sem. hr. Odd years
SPECIAL PROBLEMS IN POSTNATAL CRANIOFACIAL GROWTH AND DEVELOPMENT (5274). Growth, development, adaptation and aging of craniofacial structures and tissues (especially skeletal); somatic growth and development; clinical implications; theories of craniofacial development. Faculty - 1 sem. hr.
SPECIAL TOPICS IN BIOMEDICAL SCIENCES (5V91, 5V92). Reading and discussion of current literature pertinent to the topic of the seminar. Presentation of papers on selected topics is required for all students. May be used for multiple courses in any one semester. Faculty. Variable
TECHNIQUES IN CELL AND MOLECULAR BIOLOGY (5341). Principal methods of cellular/molecular investigation of proteins and nucleic acids including immunocytochemistry, western blotting, northern/southern blotting, radioimmunoassay, in situ hybridization, polymerase chain reaction, intracellular recording and fluorescence confocal microscopy. Mues - 1 sem. hr.
THESIS RESEARCH AND PREPARATION OF MASTER'S THESIS. (5V98) Faculty. Variable.
THE TMJ: GROWTH, DEVELOPMENT AND ADAPTATION (5279). Review of the structure and characteristics of the tissues comprising the temporomandibular joint, as well as alterations taking place during prenatal development and postnatal maturation. Current views regarding local environmental determinants of joint adaptation and of the possibilities of growth alteration are presented. Hinton -1 sem. hr.
USE AND CARE OF ANIMALS IN RESEARCH AND TRAINING (5229). Overview of the use and care of laboratory animals. Includes discussion of regulations and ethical issues. Bellinger - 1 sem. hr.