3302 Gaston Ave.
Dallas, Texas 75246
B.D.S., Fourth Military Medical University School of Dentistry,
Xi'an, China (1995)
M.D.S., Fourth Military Medical University School of Dentistry, Xi'an, China (2000)
Ph.D., Fourth Military Medical University (2003) (Dissertation research done at Shanghai Institutes for Biological Sciences, Chinese Academy of Science)
Postdoctoral Fellowship, Department of Oral Biology, Ohio State University, College of Dentistry (2006-2008)
Phosphate, critical for the maintenance of skeletal integrity, is a necessary component of important biomolecules and is central to signal transduction and cell metabolism. More than 80% of the total phosphate in the body is present in bone and tooth. The maintenance of appropriate serum phosphate levels is critical for the proper development and integrity of bone and tooth. The bone-kidney-parathyroid endocrine axes mediated by fibroblast growth factor-23 (FGF23) plays a central role in regulating phosphate homeostasis. The identification of genetic alterations in Mendelian disorders of hypophosphatemia has discolsed genes such as dentin matrix protein 1 (DMP1), phosphate regulating gene with homologies to endopeptidases on the X chromosome (PHEX) and family with sequence similarity 20C (FAM20C) as the principal mediators regulating FGF23, the phosphorus hormone. However, the exact mechanism of how these molecules mediating FGF23 remains largely unknown. One of my research interests is to dissect the signaling pathways involving FGF23 and the specific roles of each molecule in the pathways associated with the development of bone and tooth.
Hematopoietic stem cell (HSC) growth and differentiation are dependent on a specific environment that is physically located on the endosteal surface of bones, in pockets of cells referred to as "niches." Osteoblast lineage cells are found in these niches and are required for HSC growth and function. Similarly, factors that regulate HSC growth and development have striking effects on osteoclast and osteoblast lineage cells. The three members of the FAM20 proteins are highly expressed in both osteoblast lineage and HSC lineage. In vivo and in vitro loss-of-function of these molecules is associated with bone defects and blood cell differentiation defects. My second research interest is to investigate the reciprocal interactions mediated by FAM20 molecules between hematopoietic cells and osteoblast cells.
X Wang, J Liu, H Zhang, M Xiao, J Li, C Yang, X Lin, Z Wu, L Hu, X. Kong. (2003) Novel mutations in the IRF6 gene for Van der Woude syndrome. Human Genetics 113 (5): 382-386.
X Wang, J Hao, Y Xie, Y Sun, B Hernandez, A Yamoah, M Prasad, Q Zhu, JQ Feng, C Win. (2010) Expression of FAM20C in the osteogenesis and odontogenesis of mouse. J Histochem Cytochem 58 (11): 957-967.
Y Sun, M Prasad, T Gao, X Wang, Q Zhu, R D'Souza, JQ Feng, C Qin. (2010) Failure to process dentin matrix protein 1 (DMP1) into fragments leads to its loss of function in osteogenesis. J Biol Chem 285(41): 31713-22.
Q Zhu, Y Sun, M Prasad, X Wang, A Yamoah, Y Li, JQ Feng, C. Qin. (2010) Glycosaminoglycan chain of dentin sialoprotein proteoglycan. J Dent Res 89 (8): 808-812.
Y Sun, Y Lu, S Chen, M Prasad, X Wang, Q Zhu, J Zhang, H Ball, JQ Feng, WT Butler, C Qin. (2010) Key proteolytic cleavage site and full-length form of DSPP. J Dent Res 89 (5): 498-503.
Y Sun, V Gandhi, M Prasad, W Yu, X Wang, Q Zhu, JQ Feng, RJ Hinton, C Qin. (2010) Distribution of small integrin-binding ligand, N-linked glycoproteins (SIBLING) in the condylar cartilage of rat mandible. Int J Oral Maxillofac Surg 39(3): 272-281.
M Prasad, Q Xhu, Y Sun, X Wang, A Kulkarni, A Boski, JQ Feng, C Qin. (2011) Expression of dentin sialophosphoprotein in non-mineralized tissues. J Histochem Cytochem 59 (11): 1009-21.
J Zhao, Y Tian, J Xu, D Liu, X Wang, B Zhao. (2011) Endurance exercise is a leptin signaling mimetic in hypothalamus of Wister rats. Lipids Health Dis 2(10):225.
X Wang, S Wang C Li, T Gao, Y Liu, A Rangiani, Y Sun, J Hao, A George, Y Lu, J Groppe, B Yuan, J Feng, C Qin. (2012) Inactivation of a novel FGF23 regulator, FAM20C, leads to hypophosphatemic rickets in mice. PLoS Genetics 8(5): e1002708 (Cover story of May issue).
Q Zhu, M Prasad, H Kong, Y Lu, Y Sun, X Wang, A Yamoah, JQ Feng, C Qin. (2012) Partial blocking of mouse DSPP processing by substitution of Gly(451)-Asp(452) bond suggests the presence of secondary cleavage site(s). Connect Tissue Res 53(4):307-312.
Q Zhu, MP Gibson, Q Liu, Y Liu, Y Lu, X Wang, JQ Feng, C Qin. (2012) Proteolytic processing of dentin sialophosphoprotein (DSPP) is essential to dentinogenesis. J Biol Chem 287(36): 30426-35.
X Wang, S Wang, Y Lu, MP Gibson, Y Liu, B Yuan, JQ Feng, C Qin. (2012) FAM20C plays an essential role in the formation of murine teeth. J Biol Chem (in press)