Department of Biomedical Sciences
Member of the GSBS Faculty
3302 Gaston Ave.
Dallas, Texas 75246
Postdoctoral Fellow, Department of Basic Sciences, University of Texas Health Science Center at Houston, Dental Branch (1998-2003)
Ph.D., Department of Oral Pathology, Okayama University Graduate School of Dentistry, Okayama, Japan (1998)
M.S., Department of Oral and Maxillofacial Surgery, Harbin Medical University School of Dentistry, Harbin, China (1989)
D.D.S., Harbin Medical University School of Dentistry, Harbin, China (1983)
Professor with tenure, Department of Biomedical Sciences, Texas A&M University Baylor College of Dentistry (2013-present)
Associate Professor with tenure, Department of Biomedical Sciences, Texas A&M University Baylor College of Dentistry (2009-2013)
Assistant Professor, Department of Biomedical Sciences, Texas A&M University Baylor College of Dentistry (2006-2009)
Assistant Professor, Department of Endodontics, University of Texas Health Science Center at Houston, Dental Branch (2003-2006)
Visiting Scientist, Department of Oral Pathology, Okayama University School of Dentistry, Okayama, Japan (1993-1994)
Visiting Scientist, Department of Oral Surgery, Asahi University School of Dentistry, Japan (1992-1993)
Senior Assistant Professor (Lecturer), Senior Doctor, Department of Oral and Maxillofacial Surgery, Harbin Medical University School of Dentistry, China (1989-1992)
Assistant Professor, Department of Endodontics & Periodontics, Harbin Medical University School of Dentistry, China (1983-1986)
Dr. Qin's main research interest is to investigate the roles of the extracellular matrix (ECM) proteins in the formation and mineralization of dentin (the bulk tissue shaping the contour of a tooth) and bone. Dr. Qin has been seeking to understand the overall processes of tooth and bone formation by focusing upon the nature, metabolism, tissue/cell localization and functions of the ECM molecules in dentin and bone, two tissues that resemble each other in composition and mechanisms of formation. In addition to a predominant collagenous matrix, dentin and bone contain non-collagenous proteins that play vital roles in the formation of dentin by odontoblsts and in the homeostatic mechanisms of formation and breakdown of bone by osteoblasts, osteocytes and osteoclasts. Dr. Qin's research group is mainly interested in the roles of non-collagenous proteins in dentinogenesis (dentin formation) and osteogenesis (bone formation).
One of Dr. Qin's longstanding research projects focuses on the members of the SIBLING family (one category of non-collagenous proteins), which includes dentin matrix protein 1 (DMP1), dentin sialophosphoprotein (DSPP), bone sialoprotein (BSP) and osteopontin (OPN). He has made important discoveries about the structure and functions of DMP1 and DSPP, two molecules that play critical roles in dentinogenesis and osteogenesis. He discovered that DMP1 is processed into the NH2- and COOH-terminal fragments by proteolytic cleavage of specific peptide bonds, and his research work has established that the proteolytic cleavage of DMP1 at selected X-Asp bonds is an activation step essential to the formation of dentin and bone. His group discovered that, in addition to dentinogenesis, DSPP also plays a critical role for the development of cementum and alveolar bone. His lab has proven that the proteolytic cleavage of DSPP and selected X-Asp bonds activate this protein precursor. These fundamental discoveries about DMP1 and DSPP by Dr. Qin's group will have a far-reaching impact in the research fields of dentin and bone biology.
Studies of Proteins Involved in Dentinogenesis. NIH/NIDCR R01 DE005092:27-31; 07/01/04-06/30/09 (PI)
Studies of Proteins Involved in Dentinogenesis. NIH/NIDCR R01 DE005092-31 Supplement, 06/01/09-05/31/10 (PI)
Studies of the Roles of DMP1 and DSPP in Osteogenesis and Dentinogenesis. NIH/NIDCR R01 DE005092: 32-35, 07/01/09-06/30/14 (PI)
Studies of the Roles of DMP1 and DSPP in Osteogenesis and Dentinogenesis. NIH/NIDCR R01 DE005092-32A1S1 (American Recovery and Reinvestment Act of 2009-Grant), 09/23/09-08/31/11 (PI)
Studies of the Roles of DMP1 and DSPP in Osteogenesis and Dentinogenesis. NIH/NIDCR R01 DE005092-32A1S2; 03/31/10-08/31/11 (PI)
DMP1 Mutations: Defects in Odontogenesis. NIH/NIDCR R01 DE015209, 09/01/08-06/30/14 (Co-PI)
The Roles of FAM20C (DMP4) in Odontogenesis and Osteogenesis. NIH/NIDCR R01 DE022549-01A1:1-5; 12/01/12-11/30/17 (PI)
Publications selected from over 90 peer-reviewed articles:
Qin C, Cook RG, Orkiszewski RS, and Butler WT: Identification and characterization of the corboxy-terminal region of rat dentin sialoprotein (DSP). J Biol Chem 276: 904-909, 2001.
Qin C, Brunn JC, Jones J, George A, Ramachandran A, Gorski JP, and Butler WT: A comparative study of sialic acid-rich proteins in rat bone and dentin. Eur J Oral Sci 109:133-141, 2001.
Qin C, Brunn JC, Cadena E, Ridall A, Tsujigiwa H, Nagatsuka H, Nagai N, and Butler WT: The expression of dentin sialophosphoprotein gene in bone. J Dent Res 81: 392-294, 2002.
Qin C, Brunn JC, Cadena E, Ridall A and Butler WT: Dentin sialoprotein in bone and dentin sialophosphoprotein gene by osteoblasts. Conn Tissue Res 44: 179-183, 2003.
Qin C, Brunn JC, Baba O, Wygant JN, McIntyre BW, and Butler WT: Dentin sialoprotein isoforms: detection and characterization of a high molecular weight dentin sialoprotein (HMW-DSP). Eur J Oral Sci 111: 235-242, 2003.
Qin C, Brunn JC, Cook RG, Orkiszewski RS, Malone JP, Veis A, and Butler WT: Evidence for the proteolytic processing of dentin matrix protein 1: Identification and characterization of processed fragments and cleavage sites. J Biol Chem 278: 34700–34708, 2003.
Qin C, Baba O, and Butler WT: Posttranslational modifications of SIBLING proteins and their roles in osteogenesis and dentinogenesis. Crit Rev Oral Biol Med, 15: 126-136, 2004.
Baba O, Qin C, Brunn JC, Wygant JN, McIntyre BW, and Butler WT: Co-localization of dentin matrix protein 1 (DMP1) and dentin sialoprotein (DSP) at late stages of rat molar development. Matrix Biology 23:371-379, 2004.
Tartaix PH, Doulaverakis M, George A, Fisher LW, Butler WT, Qin C, Salih E, Tan M, Fujimoto Y, Spevak L, and Boskey AL: Dentin matrix protein-1: In vitro effects on hydroxyapatite formation provide insights into in vivo functions. J Biol Chem, 279:18115-18120, 2004.
Moses K D, Butler W T and Qin C: Immunohistochemical study of SIBLING proteins in reactionary dentin of rat molars at different ages. Eur J Oral Sci 114: 216-222, 2006.
Qin C, Huang B, Wygant JN, McIntyre BW, McDonald CH, Cook RG and Butler WT: A chondroitin sulfate chain attached to the bone dentin matrix protein 1 NH2-terminal fragment. J Biol Chem 281:8034-8040, 2006.
Gajjeraman S, Narayanan K, Hao J, Qin C, George A: Matrix macromolecules in hard tissues control the nucleation and hierarchical assembly of hydroxyapatite. J Biol Chem 282:1193-1204, 2007.
Qin C, D’Souza R, Feng J: Dentin Matrix Protein 1 (DMP1): New and Important Roles for Biomineralization and Phosphate Homeostasis. J Dent Res 86(12): 1134-1141, 2007.
Huang B, Sun Y, Maciejewska I, Qin D, Peng T, McIntyre B, Wygant J, Butler WT, Qin C: Distribution of SIBLING proteins in the organic and inorganic phases of rat dentin and bone. Eur J Oral Sci 116:104-112, 2008.
Huang B, Maciejewska I, Sun Y, Peng T, Qin D, Bonewald L, Maciejewska I, Butler WT, Feng J, Qin C:Identification of full-length dentin matrix protein 1 in dentin and bone. Calcif Tissue Int 82:401-410, 2008.
Peng T, Huang B, Sun Y, Lu Y, Bonewald LF, Chen S, Butler WT, Feng J, D'Souza RN, Qin C: Blocking of proteolytic processing and deletion of glycosaminoglycan side chain of mouse DMP1 by substituting critical amino acid residues. Cells Tissues Organs 189:192-197, 2009.
Maciejewska I, Qin D, Huang B, Sun Y, Mues G, Svoboda K, Bonewald LF, Butler WT, Feng J, Qin C: Distinct compartmentalization of dentin matrix protein 1 fragments in mineralized tissues and cells. Cells Tissues Organs 189:186-191, 2009.
Lin Y, Cheng YS, Qin C, Lin C, D'Souza R, Wang F: FGFR2 in the dental epithelium is essential for development and maintenance of the maxillary cervical loop, a stem cell niche in mouse incisors. Dev Dyn 238:324-330, 2009.
Maciejewska I, Cowan C, Svoboda K, Butler WT, D'Souza R, Qin C: The NH2-terminal and COOH-terminal fragments of dentin matrix protein 1 (DMP1) localize differently in the compartments of dentin and growth plate of bone. J Histochem Cytochem 57:155-166, 2009.
Sun Y, Gandhi V, Prasad M, Yu W, Wang X, Zhu Q, Feng JQ, Hinton RJ, Qin C: Distribution of small integrin-binding ligand, N-linked glycoproteins (SIBLING) in the condylar cartilage of rat mandible. Int J Oral Maxillofac Surg 39:272-281, 2010.
Gericke A, Qin C, Sun Y, Redfern R, Redfern D, Fujimoto Y, Taleb H, Butler WT, Boskey AL: Different forms of DMP1 play distinct roles in mineralization. J Dent Res 89:355-359, 2010.
Sun Y, Lu Y, Chen S, Prasad M, Wang X, Zhu Q, Zhang J, Ball H, Feng J, Butler WT, Qin C: Key proteolytic cleavage site and full-length form of DSPP. J Dent Res 89:498-503, 2010.
Zhang B, Sun Y, Chen L, Guan C, Guo L, Qin C: Expression and distribution of SIBLING proteins in the predentin/dentin and mandible of hyp mice. Oral Dis 16: 453-464, 2010 (PMID: 20233318).
Prasad M, Butler WT, Qin C: Dentin sialophosphoprotein in biomineralization. Connect Tissue Res 51:404-417, 2010 (PMID: 20367116).
Zhu Q, Sun Y, Prasad M, Wang X, Yamoah AK, Li Y, Feng J, Qin C: Glycosaminoglycan chain of dentin sialoprotein proteoglycan. J Dent Res 89:808-812, 2010 (PMID: 20400719).
Sun Y, Prasad M, Gao T, Wang X, Zhu Q, D'Souza R, Feng J, Qin C: Failure to process dentin matrix protein 1 (DMP1) into fragments leads to its loss of function in osteogenesis. J Biol Chem 285: 31713-22, 2010.
Wang X, Hao J, Xie Y, Sun Y, Hernandez B, Yamoah A, Prasad M, Zhu Q, Feng J, Qin C: Expression of FAM20C in the osteogenesis and odontogenesis of mouse. J Histochem Cytochem 58:957-967, 2010.
Sun Y, Ma S, Zhou J, Yamoah A, Feng J, Hinton R, Qin C: Distribution of small integrin-binding ligand, N-linked glycoproteins (SIBLING) in the articular cartilage of the rat femoral head. J Histochem Cytochem 58:1033-43, 2010.
Jiang B, Cao Z, Lu Y, Janik C, Lauziere S, Xie Y, Poliard A, Qin C, Ward L, Feng J: DMP1 C-terminal mutant mice recapture the human ARHR tooth phenotype. J Bone Miner 25: 2155-64, 2010.
Zhang R, Lu Y, Ye L, Yuan B, Yu S, Qin C, Xie Y, Gao T, Drezner MK, Bonewald LF, Feng JQ: Unique roles of phosphorus in endochondral bone formation and osteocyte maturation. J Bone Miner Res 26:1047-56, 2011.
Ma D, Zhang R, Sun Y, Rios HF, Haruyama N, Han X, Kulkarni AB, Qin C, Feng JQ: A novel role of periostin in postnatal tooth formation and mineralization. J Biol Chem 286:4302-9, 2011.
Lu Y, Yuan B, Qin C, Cao Z, Xie Y, Dallas SL, McKee MD, Drezner MK, Bonewald LF, Feng JQ: The biological function of DMP-1 in osteocyte maturation is mediated by its 57-kDa C-terminal fragment. J Bone Miner Res 26:331-340, 2011.
Sun Y, Chen L, Ma S, Zhou J, Zhang H, Feng JQ, Qin C: Roles of DMP1 processing in osteogenesis, dentinogenesis and chondrogenesis. Cells Tissues Organs 194:199-204, 2011.
Prasad M, Zhu Q, Sun Y, Wang X, Kulkarni A, Boskey A, Feng JQ, Qin C: Expression of dentin sialophosphoprotein in non-mineralized tissues. J Histochem Cytochem 59:1009-21, 2011.
Qin Q, Xu Y, He T, Qin C, Xu J. Normal and disease-related biological functions of Twist1 and underlying molecular mechanisms. Cell Res 22:90-106, 2012.
Zhu Q, Prasad M, Kong H, Lu Y, Sun Y, Wang X, Yamoah A, Feng JQ, Qin C: Partial blocking of mouse DSPP processing by substitution of Gly451-Asp452 bond suggests the presence of secondary cleavage site(s). Connect Tissue Res 53:307-312, 2012.
Napierala D, Sun Y, Maciejewska I, Bertin TK, Dawson B, D'Souza R, Qin C, Lee B: Transcriptional repression of the Dspp gene leads to dentinogenesis imperfecta phenotype of Colla1-Trps1 transgenic mice. J Bone Miner Res 27:1735-45, 2012.
Wang X, Wang S, Li C, Gao T, Liu Y, Rangiani A, Sun Y, Hao J, George A, Lu Y, Groppe J, Yuan B, Feng JQ, Qin C: Inactivation of a novel FGF23 regulator, FAM20C, leads to hypophosphatemic rickets in mice. PLoS Genet 8:e1002708, 2012.
Zurick KM, Qin C, Bernards MT. Adhesion of MC3T3-E1 cells bound to dentin phosphoprotein specifically bound to collagen type I. J Biomed Mater Res A 100:2492-98, 2012.
Zhu Q, Gibson MP, Liu Q, Liu Y, Lu Y, Wang X, Feng JQ, Qin C: Proteolytic processing of dentin sialophosphoprotein (DSPP) is essential to dentinogenesis. J Biol Chem 287:30426-35, 2012.
Wang X, Wang S, Lu Y, Gibson MP, Liu Y, Yuan B, Feng JQ, Qin C: FAM20C plays an essential role in the formation of murine teeth. J Biol Chem 287:35934-42, 2012.
Gibson MP, Zhu Q, Liu Q, D'Souza RN, Feng JQ, Qin C: Loss of dentin sialophosphoprotein leads to periodontal diseases in mice. J Periodontal Res 48:221-227, 2013.
Zurick KM, Qin C, Bernards MT. Mineralization induction effects of osteopontin, bone sialoprotein, and dentin phosphoprotein on a biomimetic collagen substrate. J Biomed Mater Res A 101:1571-81, 2013.
Gibson MP, Liu Q, Zhu Q, Lu Y, Jani P, Wang X, Liu Y, Paine ML, Snead ML, Feng JQ, Qin C: Role of the NH2-terminal fragment of dentin sialophosphoprotein in dentinogenesis. Eur J Oral Sci. 121:76-85, 2013.
Sun Y, Jiang Y, Liu Q, Gao T, Feng JQ, Dechow P, D'Souza RN, Qin C, Liu X: Biomimetic engineering of nanofibrous gelatin scaffolds with noncollagenous proteins for enhanced bone regeneration. Tissue Eng Part A. 19:1754-1763, 2013.
Liu Q, Gibson MP, Sun H, Qin C: Dentin sialophosphoprotein (DSPP) plays an essential role in the postnatal development and maintenance of mouse mandibular condylar cartilage. J Histochem Cytochem. In Press.
Wang X, Jung J, Liu Y, Yuan B, Lu Y, Feng J, Qin C: The specific role of FAM20C in amelogenesis. J Dent Res. In Press.
Gibson MP, Jani P, Liu Y, Wang X, Lu Y, Feng J, Qin C: Failure to process dentin sialophosphoprotein (DSPP) into fragments leads to periodontal defects in mice. Eur J Oral Sci. In Press.
Elected Vice-president of the Mineralized Tissue Group of the International and American Associations for Dental Research
Member, Nominating Committee, American Association for Dental Research
Recipient of Basic Science Faculty Research Award, Texas A&M University Baylor College of Dentistry
Member, Journal of Endodontics Editorial Board
Secretary and Treasurer, International Association for Dental Research (IADR)/American Association for Dental Research (AADR) Mineralized Tissue Group
Member, Journal of Dental Research Editorial Board
Recipient of Best Poster Award, The 9th International Conference on the Chemistry and Biology of Mineralized Tissues, Austin, TX, USA
Ethics Committee Member, American Association for Dental Research
Recipient of New Investigator Award, The 7th International Conference on the Chemistry and Biology of Mineralized Tissues, Jacksonville, FL, USA
Recipient of Hard Tissue Biology Award, Japanese Society of Hard Tissue Biology, Tokyo, Japan