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Xiaohua Liu

LiuAssistant Professor
Department of Biomedical Sciences
3302 Gaston Ave.
Dallas, Texas 75246
Phone: 214-370-7007
Fax: 214-874-4538
Google Scholar Profile

Education and Post-Graduate Training

Postdoctoral Fellowship,  Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI (2002-2010)

Ph.D., Polymer Chemistry, Tsinghua University, Beijing, China (2002)

B.E., Chemical Engineering, Tsinghua University, Beijing, China (1997)

Teaching Interests

Nano-Biomaterials and Regenerative Medicine (Course Director)

Cell and Molecular Biology of Oral and Craniofacial Tissues II (Co-Course Director)

Dental Materials

Research Interests

Each year millions of people suffer from tissue loss or organ failure, which costs billions of dollars for health care. Tissue engineering offers a promising approach for new tissue and organ regeneration. Canonical tissue engineering strategy includes cells, bioactive molecules, and scaffolds. A scaffold is an artificial extracellular matrix (ECM) and plays a crucial role to guide cell adhesion, proliferation, differentiation and tissue formation. However, one of the major challenges in tissue engineering is to develop cell-inductive scaffolding biomaterials that provide the desirable microenvironment to promote neo tissue regeneration. 

The research in my lab focuses on the development of new biomaterials and technologies for tissue regeneration. Specifically, we are interested in 1) Design and synthesis of new biomaterials and controlled drug delivery; 2) Development of injectable scaffolding systems; 3) Exploration of cell-matrix interactions in 3D; and 4) Regeneration of dental and craniofacial tissues.

Recent Grants 

  • NIH/NIDCR DE22838                                                             Liu (PI)           6/1/2013 - 5/31/2016

  • NIH/NIDCR  DE024343                                                           Liu (PI)           8/5/2014 - 6/31/2015

  • TAMU-Weizmann Collaborative Program (Israel)      Liu (PI)           9/1/2012 - 8/31/2016

  • TAMU - NSFC Research Grant (China)                              Liu (PI)          9/1/2013 - 12/31/2015

  • B-BEST Intramural Research Grant                                   Liu (PI)         10/1/2010 - 9/30/2013

Selected Publications

  1. Ma C, Jing Y, Sun H, and Liu X. "Hierarchical nanofibrous microspheres with controlled growth factor delivery for bone regeneration.  Advanced Healthcare Materials, In press.
  2. Qu T, Jing J, Ren Y, Ma C, Feng JQ, Yu Q, Liu X. "Complete pulpodentin complex regeneration by modulating the stiffness of biomimetic matrix". Acta Biomaterialia 2015, 16:60-70, NIHMS ID: NIHMS 66877.
  3. Chen F, Liu X. "Advancing biomaterials of human origin for tissue engineering.  Progress in Polymer Science, in press.
  4. Li Z, Qu T, Ding C, Ma C, Sun H, Li S, and Liu X.  Injectable gelatin derivative hydrogels with sustained vascular endothelial growth factor release for induced angiogenesis.  Acta Biomaterialia 2015, 13:88-100.  PMCID: PMC4293253.
  5. Qu T, Jing J, Jiang Y, Taylor RJ, Feng JQ, Geiger B, Liu X. "Magnesium-containing nano-structured hybrid scaffolds for enhanced dentin regeneration.  Tissue Engineering Part A  2014, 20:2422-2433.  PMCID: PMC4161063.
  6. Sachar A, Strom A, Miguel S, Serrano M, Svoboda, KH, and Liu X. “Cell-matrix and cell-cell interactions of human gingival fibroblasts on 3D nanofibrous gelatin matrices” Journal of Tissue Engineering and Regenerative Medicine 2014, DOI: 10.1002/term.1588,  PMID: 22888047.
  7. Jin H, Zhang K, Qiao C, Yuan A, Li D, Zhao L, Shi C, Xu X, Ni S, Zheng C, Liu X, Yang B, Sun H.  "Efficiently engineered cell sheet using a complex of polyethylenimine-alginate nanocomposites plus bone morphogenetic protein 2 gene to promote new bone formation."  International Journal of Nanomedicine 2014, 9:2179-90, PMCID: PMC4019610.
  8. Qu T, Liu X. "Nano-structured gelatin/bioactive glass hybrid scaffolds for the enhancement of odontogenic differentiation of human dental pulp stem cells " Journal of Materials Chemistry B 2013, 1:4764-72, PMCID: PMC:3789537.
  9. Sun Y, Jiang Y, Liu Q, Gao T, Feng JQ, Dechow P, D’Souza RN, Qin C, and Liu X. “Biomimetic engineering of nanofibrous gelatin scaffolds with noncollagenous proteins for enhanced bone regeneration” Tissue Engineering Part A 2013 19: 1754-1763;  PMCID:PMC3700013.
  10. Sachar A, Strom A, Serrano M, Benson MD, Opperman LA, Svoboda KH, Liu X. “Osteoblasts responses to three-dimensional nanofibrous gelatin scaffolds” Journal of Biomedical Material Research, Part A, 2012, 100A:3029-3041.  PMID: 22707234, NIHMSID: 393653.
  11. Strom TA, Arora A, Osborn B, Karim N, Komabayashi T, and Liu X. “Endodontic release system for apexification using  calcium hydroxide microspheres” Journal of Dental Research, 2012, 91(11): 1055-1059,  PMID: 22914537.
  12. Liu X., Holzwarth J, Ma PX " Functionalized biodegradable polymer scaffolds for tissue engineering",  Macromolecular Bioscience 2012, 12:911-919.  PMID: 22396193.
  13. Sun C, Jin X, Holzwarth JM, Liu X, Hu J, Gupte MJ, Zhao  Y, Ma P,  " Development of channeled nanofibrous scaffolds for oriented tissue engineering". Macromolecular Bioscience 2012 12:762-769.  PMCID: PMC  3679932.
  14. Liu X, Xiaobing Jin, and Peter X. Ma. “Nanofibrous hollow microspheres self-assembled from star-shaped polymers as injectable cell carriers for knee repair”. Nature Materials, 2011, 10(5):398-406. PMCID: PMC3080435.   {Highlighted by Nano Today  (2011) 225-226 “Injectable nanofibrous microspheres help new tissue growth” and Materials Today (June 2011)  “In (need of microspheres”).
  15. Wang J, Ma H, Jin X, Hu  J, Liu X. Longsheng N, Ma, PX.  "The effect of scaffold architecture on odontogenic differentiation of human dental pulp stem cells".   Biomaterials 2011, 32(31): 7822-30.  PMCID: PMC3159766.
  16.  Liu X and Ma PX. “The nanofibrous architecture of poly(L-lactic acid)-based functional copolymers” Biomaterials, 2010, 31(2): 259-269. PMCID: PMC2783301.
  17. Smith L, Liu X., Hu J, Ma, PX.  "The enhancement of human embroyonic stem cell osteogenic differentiation with nano-fibrous scaffolding.  Biomaterials 2010, 31(21): 5526-5535, PMCID: PMC2875265.
  18. Wang J, Liu X, Jin X, Ma H, Hu J, Ni L, Ma PX.  "The odontogenic differentiation of human dental pulp stem cells on nanofibrous poly(1-lactic acid) scaffolds in vitro and in vivo.  Acta Biomaterialia  2010 6 (10): 3856-3863.  PMCID: PMC3885689.
  19. Hu J, Smith L, Feng K, Liu X, Sun H, Ma PX.  "Response of human embryonic stem cell-derived mesenchymal stem cells to osteogenic factors and architectures of materials during in vitro osteogenesis.  Tissue Engineering, Part A  2010 16 (11): 3507-3514.  PMCID:  PMC2965192.
  20.  Liu X,  Smith L, Hu J, and Ma PX. “Biomimetic nanofibrous gelatin/apatite composite scaffolds for bone tissue engineering” Biomaterials, 2009, 30(12): 2252-2258. PMCID: PMC2679864.
  21. Liu X and Ma PX, "Phase separation, pore structure and properties of nanofibrous gelatin scaffolds"  Biomaterials  2009 30 (25): 4094-4103.  PMCID: PMC2744837.
  22. Smith L, Liu X, Wang P, Hu, J, and Ma PX.  Enhancing osteogenic differentiation of embroyonic stem cells by nanofibers" Tissue Engineering, Part A 2009 15:(7) 1855-1864.  PMCID: PMC2744836.
  23. Smith L, Liu X Hu J and Ma, PX.  "The influence of three-dimensional nanofibrous scaffolds on the osteogenic differentiation of embryonic stem cells" Biomaterials 2009, 30(13): 2516-22.  PMCID: PMC2679863.
  24. Hu J, Feng K, bLiu X, Ma PX. " Chondrogenic and osteogenic differentiations of human bone marrow-derived mesenchymal stem cells on a nanofibrous scaffold with designed pore network"  Biomaterials 2009, 30(28): 5061-5067.  PMCID: PMC2887482.
  25. Smith I, Liu X, Smith L, Ma PX.  "Nanostructured polymer scaffolds for tissue engineering and regenative medicine", WIREs Nanomed Nanobiotechnol 2009, 1: 226-236.
  26. Hu J, Liu X., Ma PX.  "Induction of osteoblast differentiation phenotype on poly(L-lactic acid) nanofibrous matrix", Biomaterials 2008, 29(28): 3815-3821.  NIHMSID: NIHMS66625.
  27. Smith L, Liu X, Ma PX.  "Tissue engineering with nano-fibrous scaffolds", Soft Matter 2008 (4(11): 2144-2149.  PMCID:  PMC2801146.
  28. Liu X, Pettway GJ, McCauley LK, Ma PX.  "Pulsatile release of parathroud hormone from an implantable delivery system", Biomaterials 2007 28 (28): 4123-4131.  PMCID: PMC2048537.
  29. Liu X, Won Y, Ma PX. "Porogen-induced surface modification of nano-fibrous poly (L-lactic acid) scaffolds for bone tissue engineering"  Biomaterials 2006, 27(21): 3980-3987.  PMID: 16580063.
  30. Liu X, Won Y, Ma PX.  "Surface modification of interconnected porous scaffolds  Journal of Biomedical Materials Research, Part A, 2005 74:1): 84-91.  PMID: 15937920.
  31. Liu X, Smith L, Wei G, Won Y and Ma PX. "Surface engineering of nano-fibrous poly (L-lactic acid) scaffolds via self-assembly technique for bone tissue engineering" Journal of Biomedical Nanotechnology 2005, 1:54-60.
  32. Liu X, Ma PX.  "Polymeric scaffolds for bone tissue engineering" Annals of Biomedical Engineering, 2004; 32(3): 477-486.  PMID: 15095822.

National Service/Recognition

  • Program chair of Society for Biomaterials Dental/Craniofacial Special Interest Group (2015-2017)
  • Organizer of six symposia for Society for Biomaterials (SFB), Tissue Engineering and Regenerative Medicine International Society (TERMIS), IADR/AADR, and American Anatomy Association (AAA) annual meetings (2013-2015)
  • Invited grant reviewer, Medical Research Council (MRS) of United Kingdom (2013)
  • Ad hoc reviewer for 33 journals (2013-present)
  • Editorial board member of three journals (2013-present)
  • 21 invited talks (nationally and internationally) (2011-2015)


Last edited by: jsantacruz 09/30/2015

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